[Cytochrome p-450-dependent monooxygenase in fish tissues]

Data about enzymes involved in metabolism and detoxification of xenobiotics in fish are summarized. Special attention is given to the comparison of monooxygenase systems of fish and mammals. 3-Methylcholanthrone, benzo-pyrene, benzo-naphthoflavone, and various technogenic pollutants present in water are examined as inducers of fish monooxygenase systems. The induction of cytochrome P-450 isozymes is specially reviewed, and we discuss their difference from similar isozymes of other vertebrates classes. We also discuss the relationship between the activity of the monooxygenase system in fish and temperature conditions of water bodies, as well as sex-related differences in the activity of this system. Perspective in the use of the monooxygenase system for biological monitoring are reviewed.