Related Experiment Video
Updated: Aug 12, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
[Various aspects of the effect of heparin-serotonin complex on blood and blood flow]
M V Kondashevskaia1, V I Sergeev, L A Liapina
1Moscow State University, Biological Faculty, Russia.
Abstract:
High-molecular heparin-serotonin complex (3:1 weight ratio) was obtained in vitro. The complex, its components, and heparin-serotonin mixture were introduced intraperitoneally in rats, and the resulting effects were registered 10, 30, and 60 min later. The complex had anticoagulant and lytic activities distinct from those of plasmin. According to decrease activity of factor XIII and decreased concentration of fibrinogen, the complex stimulated the anticoagulant system. In addition, the heparin-serotonin complex penetrated the hematoencephalic barrier and decreased the rate of brain bloodstream. The observed physiological properties of the heparin-serotonin complex were distinct from those of serotonin, heparin, and their mixture.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Venous Thrombosis III: Interprofessional Care

