Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet function in patients on long term peritoneal dialysis

R M Lindsay, M Friesen, F Koens

    Clinical Nephrology
    |August 1, 1976
    PubMed
    Summary

    Platelet function in end-stage renal failure patients on peritoneal dialysis showed impaired adhesiveness but normal aggregation. Peritoneal dialysis may remove factors inhibiting platelet aggregation more effectively than hemodialysis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study.

    Environmental health : a global access science source·2018
    Same author

    ECG machine QTc intervals are inaccurate in hemodialysis patients.

    Nephron. Clinical practice·2013
    Same author

    The neurotrophin family of NGF-related neurotrophic factors.

    Restorative neurology and neuroscience·2011
    Same author

    Colorimetric determination of guanidines in blood.

    Nature·2010
    Same author

    Acute renal failure.

    Canadian Medical Association journal·2010
    Same author

    The ethics of biomedicine.

    Canadian Medical Association journal·2010

    Area of Science:

    • Nephrology
    • Hematology
    • Uremic Toxins

    Background:

    • End-stage renal failure (ESRF) significantly impacts platelet function.
    • Previous studies indicate impaired platelet adhesion and aggregation in uremia.
    • Dialysis modality may influence these functional defects.

    Purpose of the Study:

    • To investigate platelet function (adhesiveness and aggregation) in patients with ESRF undergoing long-term peritoneal dialysis (PD).
    • To compare PD patients' platelet function with healthy volunteers, non-dialyzed ESRF patients, and hemodialysis (HD) patients.
    • To explore the role of uremic retention products and dialysis membrane permeability in platelet dysfunction.

    Main Methods:

    • Platelet function studies including adhesiveness and aggregation assays (using ADP and adrenaline chloride).

    Related Experiment Videos

  • Comparison of data from 18 ESRF patients on PD with existing data from other groups.
  • Analysis of the relationship between platelet function parameters and serum creatinine levels.

    • Main Results:

    • Platelet adhesiveness was impaired in PD patients, with no correlation to serum creatinine.
    • Platelet aggregation to ADP and adrenaline chloride was normal in PD patients.
    • Non-dialyzed and HD patients showed marked impairment in platelet aggregation.

    Conclusions:

    • Different uremic retention products differentially affect platelet adhesion and aggregation.
    • The peritoneal membrane appears more permeable to factors inhibiting platelet aggregation compared to conventional hemodialysis membranes.
    • These findings have implications for understanding platelet defects in uremia and assessing dialysis adequacy.