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Endothelin receptor expression in human decidua

G Kohnen1, S Campbell, G A Irvine

  • 1Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow Royal Infirmary, UK.

Molecular Human Reproduction
|May 23, 1998
PubMed
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Endothelin receptor B (ET(B)) expression increases during decidualization, a progesterone-driven process in the endometrium. This suggests endothelins play a role in pregnancy and endometrial changes.

Area of Science:

  • Reproductive Biology
  • Endocrinology
  • Cell Biology

Background:

  • Endothelins are signaling peptides acting via ET(A) and ET(B) receptors.
  • Endothelin receptors are present in the human endometrium and vary with the menstrual cycle.

Purpose of the Study:

  • To investigate changes in endothelin receptor expression during pregnancy and progestagen treatment.
  • To correlate receptor expression with basement membrane components during decidualization.

Main Methods:

  • Autoradiography using selective ET(A) and ET(B) ligands on human decidual and endometrial tissues.
  • Comparison of ligand binding with laminin alpha2 light chain and collagen IV distribution.
  • Analysis of tissues from first and third trimester pregnancies, progestagen-treated endometrium, and controls.

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Main Results:

  • ET(A) and ET(B) receptors, laminin alpha2 light chain, and collagen IV were expressed in first-trimester decidual cells.
  • ET(B) was also found on endometrial glandular epithelium.
  • A significant positive correlation was observed between ET(B) expression and laminin alpha2 light chain (P < 0.001).
  • ET(A) expression appeared reduced in the third trimester stroma.
  • Progestagen-induced decidua mirrored first-trimester decidua patterns.

Conclusions:

  • Endothelin receptor B (ET(B)) is up-regulated during progesterone-dependent decidualization.
  • Endothelins may have a paracrine or autocrine function in the decidua.
  • Changes in endothelin receptor expression are linked to endometrial remodeling during pregnancy.