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Related Experiment Videos

Absolute quinidine bioavailability

C T Ueda, B J Williamson, B S Dzindzio

    Clinical Pharmacology and Therapeutics
    |September 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    This study investigated quinidine bioavailability in hospitalized patients. Oral quinidine absorption was rapid, with bioavailability reduced by first-pass hepatic metabolism.

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    Area of Science:

    • Pharmacokinetics
    • Drug Metabolism
    • Clinical Pharmacology

    Background:

    • Quinidine is an antiarrhythmic drug with variable oral absorption.
    • Understanding quinidine bioavailability is crucial for effective therapeutic dosing.

    Purpose of the Study:

    • To determine the absolute bioavailability of quinidine after oral administration.
    • To investigate the impact of first-pass hepatic metabolism on quinidine bioavailability.

    Main Methods:

    • 11 hospitalized patients received a 400-mg dose of quinidine gluconate intravenously and orally.
    • Plasma quinidine concentrations were measured over time.
    • Area under the plasma concentration-time curve (AUC) and urinary excretion were analyzed.

    Main Results:

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    • Absolute oral bioavailability of quinidine ranged from 44% to 89% (mean 72%).
    • Peak plasma concentrations were reached within 65 minutes in most patients.
    • First-pass hepatic metabolism was predicted to reduce bioavailability by 76%.

    Conclusions:

    • Oral absorption of quinidine is rapid.
    • First-pass hepatic metabolism significantly reduces quinidine bioavailability.
    • These findings have implications for optimizing quinidine dosing strategies.