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[Current lymphoma classification: a step forward for pathologists and clinicians]

D de Jong¹, P M Kluin

¹Nederlands Kanker Instituut/Antoni van Leeuwenhoek Ziekenhuis, afd. Pathologie, Amsterdam.

Nederlands Tijdschrift Voor Geneeskunde

|August 16, 1997

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The Revised European-American Lymphoma (REAL) Classification integrates pathology and clinical data for Non-Hodgkin lymphomas. This system aids communication and the development of targeted therapies for specific lymphoma entities.

Area of Science:

Hematology
Oncology
Pathology

Context:

Non-Hodgkin lymphomas present diverse clinical and pathological features.
Effective communication among specialists requires a standardized classification system.

Purpose:

To introduce the Revised European-American Lymphoma (REAL) Classification.
To establish a unified system integrating diverse data for lymphoma classification.

Summary:

The REAL Classification (1994) merges morphological, immunohistochemical, molecular, and cytogenetic data.
It distinguishes distinct clinical-pathological entities with characteristic spectra, evolution, and presentations.
This approach facilitates a deeper understanding of lymphoma heterogeneity.

Impact:

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The REAL Classification improves communication among pathologists, clinicians, and researchers.
It enables the development of targeted therapies for specific lymphoma subtypes.
Represents a significant advancement in the field of hemato-oncology.