Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Inflammatory mechanisms in the kidney]

R P Wüthrich1

  • 1Physiologisches Institut, Universität Zürich-Irchel.

Schweizerische Medizinische Wochenschrift
|April 17, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intestinal infection at onset of mycophenolic acid-associated chronic diarrhea in kidney transplant recipients.

Transplant infectious disease : an official journal of the Transplantation Society·2016
Same author

Effect of Twice-Yearly Denosumab on Prevention of Bone Mineral Density Loss in De Novo Kidney Transplant Recipients: A Randomized Controlled Trial.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Five-year outcomes in kidney transplant patients converted from cyclosporine to everolimus: the randomized ZEUS study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
Same author

Spectophotometric intracutaneous analysis: an investigation on photodamaged skin of immunocompromised patients.

Journal of the European Academy of Dermatology and Venereology : JEADV·2014
Same author

A randomized study evaluating cinacalcet to treat hypercalcemia in renal transplant recipients with persistent hyperparathyroidism.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
Same author

Response to letter from the editor 'Complement C3 activation in cyst fluid and urine from autosomal dominant polycystic kidney disease patients'.

Journal of internal medicine·2014

Fragments of the polysaccharide hyaluronan (HA) promote kidney inflammation by upregulating adhesion molecules and chemokines in renal cells. This contributes to leukocyte infiltration and immune renal injury in various kidney diseases.

Area of Science:

  • Nephrology
  • Immunology
  • Cell Biology

Background:

  • Leukocyte infiltration into the kidney is crucial in immune-mediated renal diseases.
  • Chemokines and intercellular adhesion molecules facilitate mononuclear cell anchoring in the kidney.
  • Hyaluronan (HA) fragments, unlike native HA, upregulate adhesion molecules and chemokines in renal proximal tubular cells.

Purpose of the Study:

  • To investigate the role of hyaluronan fragments in immune renal injury.
  • To explore the mechanism by which HA fragments promote leukocyte infiltration in the kidney.

Main Methods:

  • Upregulation of adhesion molecules (ICAM-1, VCAM-1) in renal proximal tubular cells.
  • Stimulation of chemokine synthesis in renal proximal tubular cells.
  • Investigating the binding of HA fragments to the CD44 receptor.

Related Experiment Videos

Main Results:

  • HA fragments, not native HA, significantly upregulate ICAM-1 and VCAM-1 in renal proximal tubular cells.
  • HA stimulates chemokine synthesis in these renal cells.
  • HA accumulation in inflammatory renal diseases may promote leukocyte infiltration via CD44.

Conclusions:

  • HA fragments play a pro-inflammatory role in the kidney.
  • HA-mediated upregulation of adhesion molecules and chemokines contributes to leukocyte infiltration.
  • This mechanism is a potential driver of immune renal injury in various kidney diseases.