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[Inflammatory mechanisms in the kidney]

R P Wüthrich1

  • 1Physiologisches Institut, Universität Zürich-Irchel.

Schweizerische Medizinische Wochenschrift
|April 17, 1998
PubMed

Diverse mechanisms regulate the infiltration of the kidney with leukocytes in immune-mediated renal diseases. Chemotactic factors (chemokines) and intercellular adhesion molecules are known to promote the anchoring of infiltrating mononuclear cells in the kidney. We have recently shown that fragments of the polysaccharide hyaluronan (HA), but not native high molecular weight HA can cause prominent upregulation of the adhesion molecules ICAM-1 and VCAM-1 in renal proximal tubular cells. HA is also capable of stimulating the synthesis of chemokines in these cells. HA accumulates in many inflammatory renal diseases and could cause a proinflammatory effect by promoting leukocyte infiltration in the kidney after binding with its cellular receptor CD44. This mechanism may play an important role in immune renal injury in various renal diseases.

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