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New imidazole alkaloids and zinc complexes from the micronesian sponge Leucetta cf. chagosensis
X Fu1, F J Schmitz, R S Tanner
1Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.
Journal of Natural Products
|April 17, 1998
Abstract:
Four new imidazole alkaloids, 2-5, along with the known isonaamidine B (1) were isolated from a Pacific sponge, Leucetta cf. chagosensis, collected from Yap, Federated States of Micronesia. Among these, 4 and 5 are zinc complexes derived from isonaamidine B and isonaamidine D. The structures of the new compounds were elucidated from spectral data. Isonaamidine D (3) showed weakly antifungal activity against Aspergillus niger with MIC = 100 micrograms/mL.