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Cremimycin, a novel 19-membered macrocyclic lactam antibiotic, from Streptomyces sp
M Igarashi1, T Tsuchida, N Kinoshita
1Institute of Microbial Chemistry, Tokyo, Japan.
The Journal of Antibiotics
|April 17, 1998
Abstract:
A novel 19-membered macrocyclic lactam antibiotic, cremimycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MJ635-86F5, was identified as a member of Streptomyces. Cremimycin was isolated from the mycelial cake by extraction with CHCl3-MeOH and precipitation with hexane-MeOH. The structure of cremimycin was determined by spectroscopic study. Cremimycin showed broad antimicrobial activities against Gram-positive bacteria including MRSA.