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Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites
1Research Center for Biological Function, The Kitasato Institute, Tokyo, Japan.
The Journal of Antibiotics
|April 17, 1998
Abstract:
In the course of our screening program for artemisinin-like antimalarial compounds from microorganisms, seven fungal metabolites such as radicicol and heptelidic acid were identified as active compounds. Some of them exhibited antimalarial activity in vitro against the human malaria parasite Plasmodium falciparum to the extent of approximately 1/10 as potent as artemisinin. Radicicol was moderately active in vivo against Plasmodium berghei in mice.