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Synthesis and activity of 3-epi-actinobolin
H Adachi1, Y Nishimura, S Kondo
1Institute of Microbial Chemistry, Tokyo, Japan.
The Journal of Antibiotics
|April 17, 1998
Abstract:
3-epi-Actinobolin was synthesized by the chemical transformation of actinobolin involving a key step of the reconstruction of fused delta-lacton skeleton via intramolecular acylation reaction. The analogue with low toxicity weakly inhibits Gram-positive and Gram-negative bacteria.