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Related Experiment Videos

Famotidine-associated mental status changes

P T Rodgers1, G R Brengel

  • 1School of Pharmacy, Virginia Commonwealth University, Richmond 23298-0533, USA.

Pharmacotherapy
|April 17, 1998
PubMed
Summary

Elderly patients may experience central nervous system side effects, such as confusion, from oral famotidine. Discontinuation and rechallenge confirmed famotidine as the cause of these adverse events.

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Area of Science:

  • Pharmacology
  • Geriatric Medicine
  • Neuroscience

Background:

  • Ranitidine, a histamine-2 antagonist, was replaced with famotidine for dyspepsia in a 77-year-old man.
  • Histamine-2 antagonists are commonly used for acid-related gastrointestinal disorders.

Observation:

  • The patient developed confusion, disorientation, and nightmares after starting oral famotidine.
  • Symptoms resolved upon famotidine discontinuation and recurred upon rechallenge.
  • Visual hallucinations were noted during the rechallenge phase.

Findings:

  • This case suggests a potential link between oral famotidine and central nervous system adverse effects.
  • The patient experienced significant mental status changes, including hallucinations.
  • This is the first reported instance in an ambulatory patient on oral famotidine.

Implications:

  • The elderly may be more susceptible to famotidine-induced central nervous system effects.
  • Clinicians should consider famotidine's potential neuropsychiatric side effects in elderly patients.
  • This case highlights the importance of considering medication side effects in geriatric patients with altered mental status.

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