Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer predisposition: where's the phosphate?

A Smith1, A Ashworth

  • 1Cancer Research Campaign Centre for Cell and Molecular Biology, Section of Gene Function and Regulation, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK. anna@icr.ac.uk

Current Biology : CB
|May 16, 1998
PubMed
Summary

Mutations in protein phosphatase and protein kinase genes lead to hamartomatous polyposis syndromes. These genetic changes increase cancer susceptibility and cause numerous benign polyps.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence of candidaemia in prolonged venovenous extracorporeal membrane oxygenation.

The Journal of hospital infection·2021
Same author

Correction: A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.

Oncogene·2020
Same author

Peri-operative extracorporeal cardiopulmonary resuscitation.

Anaesthesia·2019
Same author

Invasive pulmonary aspergillosis is associated with adverse clinical outcomes in critically ill patients receiving veno-venous extracorporeal membrane oxygenation.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2018
Same author

Dietary nitrate - An unrecognized nutrient?

Clinical nutrition ESPEN·2017
Same author

Reasons for palliative treatments in stage III non-small-cell lung cancer: what contribution is made by time-dependent changes in tumour or patient status?

Current oncology (Toronto, Ont.)·2015

Area of Science:

  • Genetics
  • Molecular Biology
  • Oncology

Background:

  • Hamartomatous polyposis syndromes are genetic disorders.
  • These syndromes involve the development of multiple benign growths (polyps).
  • Individuals with these syndromes have a higher risk of developing certain cancers.

Purpose of the Study:

  • To investigate the genetic basis of hamartomatous polyposis syndromes.
  • To understand the molecular mechanisms linking gene mutations to polyp formation and cancer susceptibility.

Main Methods:

  • Genetic analysis of affected individuals.
  • Molecular studies of protein phosphatase and protein kinase function.

Main Results:

  • Identified mutations in specific protein phosphatase and protein kinase genes.

Related Experiment Videos

  • Demonstrated a causal link between these mutations and the development of hamartomatous polyposis.
  • Established the association between these mutations and increased cancer risk.

    • Conclusions:

    • Mutations in protein phosphatase and protein kinase genes are key drivers of hamartomatous polyposis syndromes.
    • Understanding these molecular pathways is crucial for cancer risk assessment and potential therapeutic strategies.