Depressive syndrome induced by oral contraceptives

It has been demonstrated that a small proportion of women taking oral contraceptives develop a depressive syndrome characterized by despondency, tension, and changes in sex desire. Although disturbed tryptophan metabolism induced by estrogen has been held responsible for this syndrome, the role of psychological factors should not be overlooked. Recognition and management of the syndrome require information concerning the pharmacological actions of oral contraceptives and the personality make-up of the patient.