Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pleurodesis in malignant pleural effusion]

G M Bronner1, P Baas, J H Beijnen

  • 1Slotervaartziekenhuis, afd. Apotheek, Amsterdam.

Nederlands Tijdschrift Voor Geneeskunde
|April 18, 1998
PubMed
Summary

Malignant pleural effusions, often from thoracic or ovarian cancers, cause significant symptoms. Pleurodesis using sclerosing agents is the standard treatment, though it can cause chest pain and fever.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complexation study of the anticancer agent EO-9 with 2-hydroxypropyl-beta-cyclodextrin.

Drug development and industrial pharmacy·2008
Same author

GMP production of pDERMATT for vaccination against melanoma in a phase I clinical trial.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2008
Same author

Phase I pharmacokinetic and pharmacodynamic study of the prenyl transferase inhibitor AZD3409 in patients with advanced cancer.

British journal of cancer·2008
Same author

Quantification of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in dried blood spots by liquid chromatography-triple quadrupole mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2008
Same author

A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours.

British journal of cancer·2008
Same author

Inductively coupled plasma mass spectrometric analysis of the total amount of platinum in DNA extracts from peripheral blood mononuclear cells and tissue from patients treated with cisplatin.

Analytical and bioanalytical chemistry·2008

Area of Science:

  • Oncology
  • Pulmonology
  • Thoracic Surgery

Context:

  • Malignant pleural effusions account for approximately 50% of diagnosed cases.
  • These effusions are frequently associated with thoracic, pulmonary, and ovarian cancers, as well as lymphomas.
  • Fluid accumulation results from pleural metastasis and lymphatic obstruction, leading to symptoms like dyspnea.

Purpose:

  • To review the management of malignant pleural effusions.
  • To discuss the limitations of surgical interventions such as drainage and pleural resection.
  • To highlight pleurodesis as the current standard treatment and its associated adverse effects.

Summary:

  • Malignant pleural effusions necessitate intervention when systemic treatments fail to resolve symptoms like chest discomfort and dyspnea.
  • Surgical options including needle aspiration, drainage, pleural resection, and shunts have drawbacks including recurrence and high morbidity.
  • Pleurodesis, typically performed with sclerosing agents like tetracycline, bleomycin, or talc via a drain, is the preferred method, with common side effects being chest pain and fever.

Impact:

  • Provides an overview of malignant pleural effusion causes and management strategies.
  • Discusses the efficacy and limitations of various therapeutic interventions.
  • Informs clinical practice regarding the standard treatment of pleurodesis and its potential adverse events.

Related Experiment Videos