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[The results of recent research in neurocutaneous syndromes]
1Department of Neurobiology, School of Life Sciences, Tottori University Faculty of Medicine, Yonago.
No to Hattatsu = Brain and Development
|April 18, 1998
Abstract:
Identification of NF1, TSC2 and TSC1 genes has enabled us to focus on their function and regulation. Evidence suggests that these genes are tumor suppressor genes. Malignant tissues in NF1 and hamartomatous tissues in TSC show "loss of heterozygosity" in NF1 and TSC1, 2 genes, respectively. In addition, in the Eker rat with hereditary renal carcinoma, a mutation in the TSC2 gene has been identified. In this review I mentioned briefly several issues to be clarified in the near future.