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Related Experiment Videos

Pick's disease: a modern approach

D W Dickson1

  • 1Department of Research, Mayo Clinic Jacksonville, Florida 32224, USA. dickson.dennis@mayo.edu

Brain Pathology (Zurich, Switzerland)
|April 18, 1998
PubMed
Summary

Pick's disease is a rare dementia characterized by brain atrophy and Pick bodies. Abnormal tau proteins form these inclusions, but a specific marker and genetic cause remain unknown.

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Area of Science:

  • Neurology
  • Neuroscience
  • Pathology

Background:

  • Pick's disease is a rare, familial dementing disorder.
  • Characterized by cortical atrophy and intraneuronal inclusions (Pick bodies).
  • Clinical presentation overlaps with other neurodegenerative disorders.

Purpose of the Study:

  • To summarize the key pathological and clinical features of Pick's disease.
  • To highlight recent findings regarding tau pathology.
  • To identify areas lacking definitive diagnostic markers.

Main Methods:

  • Review of pathological findings including neuronal loss, Pick bodies, and glial reactions.
  • Analysis of neurochemical deficits in neurotransmitter systems.
  • Biochemical and immunocytochemical studies of tau proteins.

Main Results:

  • Cortical atrophy predominantly affects frontal and temporal lobes.
  • Pick bodies are intraneuronal inclusions, primarily composed of abnormal tau.
  • Neuronal loss is prominent in the limbic system.
  • Tau-immunoreactive glial inclusions and neuritic changes are recognized findings.
  • Neurochemical studies show deficits in intrinsic cortical systems.

Conclusions:

  • Abnormal tau proteins are the main component of Pick bodies.
  • Distinct tau immunoblotting patterns may differentiate Pick's disease from Alzheimer's disease.
  • A specific molecular marker and genetic locus for familial Pick's disease are yet to be identified.

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