Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The microcirculation in venous hypertension

P D Coleridge Smith1

  • 1Department of Surgery, UCL Medical School, Middlesex Hospital, London, UK.

Vascular Medicine (London, England)
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic venous disease.

Minerva cardioangiologica·2007
Same author

Procollagen type I gene expression and cell proliferation are increased in lipodermatosclerosis.

The British journal of dermatology·2005
Same author

Relationship of plasma vascular endothelial growth factor to CEAP clinical stage and symptoms in patients with chronic venous disease.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2003
Same author

Deleterious effects of white cells in the course of skin damage in CVI.

International angiology : a journal of the International Union of Angiology·2003
Same author

Increased plasma total nitric oxide among patients with severe chronic venous disease.

International angiology : a journal of the International Union of Angiology·2002
Same author

Role of superficial venous surgery in the treatment of venous ulceration.

The British journal of surgery·1999
Same journal

Predictors and clinical course of chronic limb-threatening ischemia with hemodynamic failure after endovascular therapy.

Vascular medicine (London, England)·2026
Same journal

Bigger isn't always scarier: Aneurysm size and illness perception in thoracic aortic aneurysm patients undergoing surveillance.

Vascular medicine (London, England)·2026
Same journal

Initiation of an emergency department discharge pathway for low-risk patients with venous thromboembolism: Factors impact real-world practice.

Vascular medicine (London, England)·2026
Same journal

'It works in practice, but does it work in theory?' An important addition to the body of real-world evidence supporting carotid endarterectomy.

Vascular medicine (London, England)·2026
Same journal

Carotid endarterectomy and stenting in France: A 10-year nationwide evaluation of practice and outcomes.

Vascular medicine (London, England)·2026
Same journal

Images in Vascular Medicine: When coronary anatomy goes the wrong way-A diagnostic challenge.

Vascular medicine (London, England)·2026
See all related articles

Venous ulceration is linked to skin microcirculation issues, not just nutrient diffusion failure. Leukocyte activation and endothelial injury are key factors in this chronic inflammatory condition.

Area of Science:

  • Vascular biology
  • Dermatology
  • Pathophysiology

Background:

  • Venous ulceration is a prevalent condition in Western countries, imposing significant healthcare costs.
  • The precise mechanisms underlying venous ulceration development remain incompletely understood.
  • Current research emphasizes the role of the skin's microcirculation in ulcer pathogenesis.

Purpose of the Study:

  • To review principal findings on the microcirculation in venous ulceration.
  • To evaluate hypotheses regarding the development of venous ulceration.
  • To elucidate the role of inflammatory processes in venous ulceration.

Main Methods:

  • Review of published research on skin microcirculation in venous ulceration.
  • Analysis of investigative methods used to study cutaneous microcirculation.

Related Experiment Videos

  • Evaluation of evidence for different etiological hypotheses.

    • Main Results:

    • Evidence suggests venous ulceration is unlikely caused solely by impaired diffusion of oxygen and nutrients.
    • Microvascular changes include activated endothelium and perivascular inflammatory cells.
    • Leukocyte adhesion, activation, and subsequent endothelial injury are implicated in the pathogenesis.

    Conclusions:

    • Chronic inflammation, driven by leukocyte-endothelial interactions, likely leads to lipodermatosclerosis and tissue changes.
    • While leukocyte involvement is evident, exact pathogenic mechanisms require further investigation.
    • A deeper understanding of venous ulceration's causes may lead to improved therapeutic strategies.