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Related Experiment Videos

Pain and Stroop interference tasks activate separate processing modules in anterior cingulate cortex

S W Derbyshire1, B A Vogt, A K Jones

  • 1University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK.

Experimental Brain Research
|April 18, 1998
PubMed
Summary
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The anterior cingulate cortex (ACC) is involved in multiple cognitive processes, not just attention. Functional imaging reveals independent ACC activation sites for pain and cognitive tasks, challenging the idea of a singular attentional role.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Pain Research

Background:

  • Functional imaging studies identify a widespread central network for nociception, including the anterior cingulate cortex (ACC).
  • Previous research suggests ACC activation during cognitive tasks like the Stroop task, leading to interpretations of its role in general attention rather than specific pain processing.

Purpose of the Study:

  • To investigate the role of the ACC in pain processing using advanced functional imaging techniques.
  • To differentiate the ACC's involvement in pain perception versus cognitive tasks like the Stroop task.

Main Methods:

  • Utilized three-dimensional positron emission tomography (PET) to assess regional cerebral blood flow (rCBF).
  • Employed coregistration of PET and magnetic resonance (MR) images for precise localization of brain activity.

Related Experiment Videos

  • Assessed rCBF during noxious heat stimulation and subtracted baseline heat images; also assessed rCBF during the Stroop task.

    • Main Results:

    • Identified two distinct regions of elevated rCBF in the ACC during pain: the perigenual region and the midcingulate cortex.
    • Group analysis showed overlap between midcingulate activation during pain and the Stroop task.
    • Individual subject analysis revealed widespread, independent ACC activation patterns for pain and the Stroop task, contradicting the group overlap finding.

    Conclusions:

    • The ACC is implicated in a variety of cognitive procedures, extending beyond a simple role in attention.
    • The distinct and independent activation sites for pain and cognitive tasks suggest the ACC's contribution to pain processing is not solely mediated by attention.
    • It is insufficient to characterize the ACC's primary role in pain as "attention" due to the complex and distributed nature of its activation patterns.