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[Structural brain changes in the computerized tomography of schizophrenic patients]

A Szulc1

  • 1Kliniki Chorób Psychicznych AM w Białymstoku.

Psychiatria Polska
|April 18, 1998
PubMed
Summary

Schizophrenia patients exhibit enlarged ventricles and more frequent cortical atrophy compared to controls. Ventricular-brain ratio (VBR) negatively correlated with negative symptoms, suggesting structural brain changes in schizophrenia.

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neurology

Background:

  • Schizophrenia is a complex psychiatric disorder associated with various neurobiological alterations.
  • Previous studies have indicated potential structural brain abnormalities in individuals with schizophrenia, including ventricular enlargement and cortical atrophy.

Purpose of the Study:

  • To investigate the relationship between ventricular-brain ratio (VBR) and cortical atrophy in patients with schizophrenia.
  • To explore correlations between VBR, negative symptoms, and demographic factors in schizophrenia.

Main Methods:

  • A comparative study design was employed, analyzing neuroimaging data from schizophrenic patients and a control group.
  • Ventricular-brain ratio (VBR) was calculated, and the frequency of cortical atrophy was assessed.

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  • Correlations between VBR, Scale for the Assessment of Negative Symptoms (SANS), and Positive and Negative Syndrome Scale (PANSS) negative subscores were examined.

    • Main Results:

    • Schizophrenia patients showed a significantly higher VBR and more frequent cortical atrophy compared to the control group.
    • VBR demonstrated a negative correlation with SANS and PANSS negative scores, particularly with alogia and inattention.
    • A positive correlation was observed between VBR and female sex.
    • Positive intercorrelations were found among VBR and other lateral ventricular ratios, but not with cortical atrophy.

    Conclusions:

    • Elevated VBR and increased cortical atrophy are significant neuroimaging findings in schizophrenia.
    • These structural changes correlate with specific negative symptoms, suggesting a link between ventricular enlargement and symptom severity.
    • The findings highlight the utility of VBR as a potential imaging biomarker in schizophrenia research.