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[Medical rhabdomyolysis in the elderly]
A Fernández-Fúnez1, J C Segura Luque, R Tirado Miranda
1Servicio de Medicina Interna, Hospital General de Albacete.
Revista Clinica Espanola
|April 18, 1998
Summary
Elderly patients experience rhabdomyolysis (RM) primarily from immobilization and infections, with a higher risk of acute renal failure (ARF). ARF in the elderly is linked to hypoalbuminemia and is more persistent, impacting mortality rates.
Area of Science:
- Geriatric Medicine
- Nephrology
- Internal Medicine
Context:
- Rhabdomyolysis (RM) is a clinical syndrome with diverse etiologies.
- Understanding RM characteristics in elderly populations is crucial due to age-related physiological changes.
- This study compares RM in elderly patients (ERM) with younger patients (YRM).
Purpose:
- To investigate the distinct characteristics of medical rhabdomyolysis (RM) in elderly patients.
- To compare RM presentation, causes, and outcomes between elderly and younger individuals.
Summary:
- A prospective study of 129 patients (56 elderly, 73 younger) revealed different RM triggers: immobilization/infections in the elderly versus physical exertion in the young.
- Elderly patients had a significantly higher incidence of acute renal failure (ARF) (OR: 5.2), associated with hypoalbuminemia.
- While hypocalcemia was present in both groups with ARF, it was more prolonged in the elderly. Mortality was higher in elderly patients who developed ARF.
Impact:
- Highlights the increased risk of ARF and its association with hypoalbuminemia in elderly patients with RM.
- Provides insights into age-specific RM management and risk stratification.
- Emphasizes the critical role of ARF in the prognosis of rhabdomyolysis in older adults.