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Recent paramethoxyamphetamine deaths

H E Felgate1, P D Felgate, R A James

  • 1Forensic Science, Adelaide, South Australia, Australia.

Journal of Analytical Toxicology
|April 21, 1998
PubMed
Summary
This summary is machine-generated.

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Paramethoxyamphetamine (PMA), often sold as "ecstasy", is a dangerous drug. Toxicology reports show PMA is more toxic than MDMA, with levels above 0.5 mg/L linked to adverse effects.

Area of Science:

  • Forensic Toxicology
  • Pharmacology
  • Illicit Drug Analysis

Background:

  • Paramethoxyamphetamine (PMA) is a substituted amphetamine derivative illicitly used in Australia since 1994.
  • PMA is frequently misrepresented as methylenedioxymethamphetamine (MDMA), commonly known as "ecstasy".

Observation:

  • This study details methods for PMA extraction, identification, and quantitation.
  • Toxicology findings from six fatalities and three non-fatal cases involving PMA are presented.

Findings:

  • Femoral blood PMA concentrations ranged from 0.24 to 4.9 mg/L (mean 2.3 mg/L).
  • Liver PMA concentrations ranged from 1.4 to 21 mg/kg (mean 8.9 mg/kg).
  • Other amphetamines were detected in five of the six fatal cases.

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Implications:

  • PMA demonstrates higher toxicity compared to MDMA.
  • Blood PMA levels exceeding 0.5 mg/L are likely associated with toxicological effects.
  • These findings highlight the critical need for accurate identification and monitoring of PMA in forensic toxicology.