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Related Experiment Videos

Ventilatory drive during exercise in congestive heart failure

G A MacGowan1, A Cecchetti, S Murali

  • 1Division of Cardiology, University of Pittsburgh School of Medicine, Pennsylvania, USA.

Journal of Cardiac Failure
|April 21, 1998
PubMed
Summary

In heart failure patients and healthy individuals, ventilatory drive, measured by the ventilatory equivalent for carbon dioxide, typically decreases during exercise. Continuous increases are rare, indicating carbon dioxide does not excessively stimulate ventilation.

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Area of Science:

  • Cardiology
  • Pulmonary Physiology
  • Exercise Science

Background:

  • Congestive heart failure (CHF) patients experience exercise intolerance, dyspnea, and fatigue.
  • The ventilatory equivalent for carbon dioxide (VE/VCO2) is an index of ventilatory drive during exercise.
  • Abnormal VE/VCO2 patterns may indicate non-cardiac factors contributing to symptoms in CHF.

Purpose of the Study:

  • To investigate the pattern of ventilatory drive during exercise in CHF patients.
  • To determine if elevated ventilatory drive is linked to factors other than carbon dioxide production in CHF.

Main Methods:

  • Symptom-limited exercise testing with gas-exchange analysis.
  • Eighty-five CHF patients across four functional classes (A-D) and 17 healthy controls participated.

Related Experiment Videos

  • Ventilatory equivalent for carbon dioxide (VE/VCO2) was measured at rest, anaerobic threshold, and peak exercise.

    • Main Results:

    • In all groups, VE/VCO2 decreased from rest to anaerobic threshold (P < .0001).
    • Three CHF patients exhibited a continuous increase in ventilatory drive.
    • Class D CHF patients showed higher resting, anaerobic threshold, and peak exercise VE/VCO2 compared to other groups (P < .01).

    Conclusions:

    • Ventilatory drive (VE/VCO2) generally decreases during exercise in CHF patients and controls.
    • Continuous increases in ventilatory drive during exercise are uncommon in CHF.
    • Findings suggest factors other than CO2 production do not excessively stimulate ventilation in most CHF patients during exercise.