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A mitogenic and hormonal signalling network regulate mammalian cell division commitment time
L Jimenez de Asua1, M Goin, M Ortiz
1Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), Buenos Aires, Argentina.
Advances in Experimental Medicine and Biology
|January 1, 1997
Abstract:
A basic property of mammalian cells is to retain the mitogenically induced "commitment" to undergo DNA replication even in the absence of stimuli. Recent findings on PGF2 alpha and hormone-induced Swiss 3T3 cell multiplication, reveal that this crucial cell cycle event can be regulated by several signalling mechanisms.