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Paternal centrosomal dynamics in early human development and infertility

A H Sathananthan1

  • 1La Trobe University, Melbourne, Australia.

Journal of Assisted Reproduction and Genetics
|April 21, 1998
PubMed
Summary

The human sperm centrosome is inherited during fertilization and organizes cell division throughout early embryonic development. Defects in this paternal centrosome can lead to abnormal cleavage and infertility.

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Area of Science:

  • Reproductive Biology
  • Cell Biology
  • Developmental Biology

Background:

  • The centrosome is a critical organelle for cell division.
  • Its role and inheritance in human early development are not fully understood.

Purpose of the Study:

  • To elucidate the dynamic behavior of the human sperm centrosome during fertilization and early embryonic cleavage.
  • To investigate the functional contribution of the paternal centrosome in human embryogenesis.

Main Methods:

  • Transmission electron microscopy (TEM) was employed.
  • Human gametes, fertilized oocytes, and preimplantation embryos were analyzed.

Main Results:

  • The functional sperm centrosome, containing a proximal centriole, is inherited during fertilization, forming a sperm monoaster.

Related Experiment Videos

  • This paternal centrosome replicates and organizes the mitotic apparatus throughout cleavage stages up to the blastocyst.
  • While bipolar spindles are typical, dispermic embryos can exhibit abnormal configurations like tripolar spindles.
  • Maternal centrosomes appear non-functional in early human development.

    • Conclusions:

    • The human embryo exhibits paternal centrosome inheritance and perpetuation, consistent with patterns observed in other animals.
    • Defective centrosome inheritance is implicated as a potential cause of abnormal embryonic cleavage and human infertility.