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A communicating intestinal duplication in a Sprague-Dawley rat
C S Elangbam1, K J Clevidence, C B Jackson
1WIL Research Laboratories, A Subsidiary of Great Lakes Chemical Corporation, Ashland, Ohio 44805, USA. elangbam@Wilresearch.com
Toxicologic Pathology
|April 21, 1998
Summary
A rare communicating intestinal duplication was found in a Sprague-Dawley rat. This is the first documented case in this laboratory animal model, offering insights into gastrointestinal anomalies.
Area of Science:
- Veterinary Pathology
- Comparative Anatomy
- Gastroenterology
Background:
- Gastrointestinal duplications are rare congenital anomalies.
- Their occurrence in laboratory animals, particularly rats, is exceptionally uncommon.
Observation:
- A 17-week-old Sprague-Dawley rat presented with a communicating intestinal duplication.
- The duplication was located on the mesenteric border of the ileum.
- Both ends of the duplication communicated with the ileal lumen.
Findings:
- Histological examination revealed a thick muscle wall in the duplicated segment.
- The mucosa of the duplication was similar to that of the normal small intestine.
- This represents the first reported instance of intestinal duplication in a Sprague-Dawley rat.
Implications:
- This case expands the understanding of congenital gastrointestinal abnormalities in rodent models.
- It provides a unique case study for comparative pathology and research into intestinal development.
- Highlights the importance of thorough examination in laboratory animal diagnostics.
