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Inhibition of ornithine decarboxylase by ifenprodil
L Badolo1, J Dubois, M Helson-Cambier
1Laboratory of Bioanalytical Chemistry, Toxicology and Applied Physical Chemistry, Institute de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium.
European Journal of Pharmacology
|April 21, 1998
Abstract:
Ifenprodil (NMDA receptor antagonist) was tested as an inhibitor of ornithine decarboxylase. It was found that ifenprodil inhibited ornithine decarboxylase activity with the same potency as alpha-difluoromethylornithine, a major inhibitor of ornithine decarboxylase. This result suggests that ifenprodil could target either the polyamine site on the NMDA receptor complex or/and polyamine biosynthesis.