Related Experiment Video

Updated: Aug 2, 2026

Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils
08:09

Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils

Published on: November 16, 2015

T-cell subsets in adenoids and peripheral blood related to age, otitis media with effusion and allergy

E Lagging1, G Papatziamos, G Halldén

  • 1Department of Laboratory Medicine, Karolinska Hospital, Stockholm, Sweden.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|April 21, 1998
PubMed

Insights

Adenoids play a role in developing immunological memory, with memory T-cells being more prevalent there than in blood. Allergy in children is linked to these adenoid memory cells.

Area of Science:

  • Immunology
  • Pediatrics
  • Cell Biology

Background:

  • Adenoids are key immune tissues in children.
  • Otitis media with effusion (OME) and obstructive adenoid hyperplasia are common pediatric conditions.
  • Understanding T-lymphocyte profiles in adenoids is crucial for pediatric immunology.

Purpose of the Study:

  • To investigate the T-lymphocyte profile in adenoids and peripheral blood of children.
  • To explore the relationship between age, allergy, and T-lymphocyte phenotypes in adenoids.
  • To determine if adenoids contribute to immunological memory development.

Main Methods:

  • Flow cytometry was used to analyze T-lymphocyte populations (CD4+, CD8+, CD45RO+) in adenoid and blood samples.
  • 29 children (20-120 months) undergoing adenoidectomy were studied.
  • Children with OME, obstructive adenoid hyperplasia, and allergies were included.

Main Results:

  • Memory T-helper cells (CD4+/CD45RO+) were significantly higher in adenoids compared to blood.
  • Memory T-helper cell percentage increased with age in peripheral blood.
  • Allergic children showed a higher CD4+/CD8+ ratio for memory cells in adenoids.

Conclusions:

  • Adenoids are involved in the development of immunological memory.
  • A correlation exists between childhood allergies and the presence of memory cells in adenoids.
  • These findings highlight the immune significance of adenoids in pediatric health.

More Related Videos

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue07:38

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue

Published on: June 14, 2020

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD22608:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...