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Pyogenic hepatic abscess. A 10-year population-based retrospective study

P S Hansen1, H C Schønheyder

  • 1Department of Clinical Microbiology, Aalborg Hospital, Denmark.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|April 21, 1998
PubMed
Summary

Pyogenic hepatic abscesses (PHA) are rare, often presenting with fever. Treatment involves antibiotics and drainage, with a low fatality rate, suggesting fewer underlying malignant conditions.

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Microbiology

Background:

  • Pyogenic hepatic abscesses (PHA) are uncommon liver infections.
  • Understanding the epidemiology and microbiology of PHA is crucial for effective management.

Purpose of the Study:

  • To analyze the clinical characteristics, causative pathogens, and treatment outcomes of pyogenic hepatic abscesses.
  • To determine the incidence and case fatality rate of PHA.

Main Methods:

  • A 10-year retrospective survey of patients diagnosed with PHA.
  • Analysis of patient symptoms, laboratory findings, microbial cultures (pus and blood), and treatment modalities.

Main Results:

  • Mean annual incidence of PHA was 11/1,000,000. Fever was the primary symptom.

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  • Enteric Gram-negative rods (45%) and anaerobic bacteria (31%) were the most common isolates from abscess pus.
  • Percutaneous drainage and systemic antibiotics were the main treatment strategies, with a 6% overall case fatality rate.

    • Conclusions:

    • PHA is a rare condition with characteristic microbial profiles.
    • Effective management includes prompt diagnosis, appropriate antibiotic therapy, and drainage procedures.
    • The low case fatality rate may indicate a lower prevalence of associated malignant diseases in this patient cohort.