Loss of an adrenergic effect in swiss mice

The effect of adrenaline on the amount of blood eosinophils (eosinophilia) which had been found in Swiss mice in earlier experiments was lost after a few generations. The hyperglycemic response to adrenaline had not been changed. Sensitivities to noradrenaline and adrenaline were as found earlier, but the sensitivity to isoprenaline was reduced. The reduction of beta-adrenergic responsiveness suggests variations in biochemical parameters of mice or the appearance of mice genetically less responsive to beta-adrenergic drugs in only a few generations.