Double choroidal malignant melanoma in an eye with apparent clinical regression
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Updated: Oct 30, 2026
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
D E Holck1, J J Dutton, S D Pendergast
1Department of Ophthalmology, Wilford Hall Medical Center, San Antonio, Texas 78236, USA.
Abstract:
Multicentric melanomas in the same eye are rare, with few cases substantiated by histology and serial sectioning. We report a patient with two documented choroidal malignant melanomas in one eye. The initial tumor spontaneously decreased in size for over 2 years before a second tumor appeared in a noncontiguous location in the same eye. After enucleation, serial sections showed that the two lesions were independent choroidal melanomas. We review the literature regarding multiple, independent intraocular choroidal malignant melanomas.
Insights
Multicentric melanomas are rare, but this case documents two independent choroidal malignant melanomas in one eye. Histological analysis confirmed the distinct nature of these rare intraocular tumors.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Multicentric choroidal melanomas, particularly within the same eye, represent a rare clinical presentation.
- Histological and serial sectioning evidence is crucial for substantiating the independent nature of multiple intraocular tumors.
Observation:
- A patient presented with two distinct choroidal malignant melanomas within the same eye.
- The initial tumor exhibited spontaneous regression over a two-year period.
- A second, noncontiguous tumor subsequently emerged in the same eye.
Findings:
- Serial sectioning after enucleation confirmed the presence of two independent choroidal malignant melanomas.
- The lesions were histologically distinct, supporting their multicentric origin.
Implications:
- This case highlights the possibility of developing multiple, independent choroidal melanomas in a single eye.
- The findings contribute to the understanding of the natural history and behavior of intraocular melanomas.
- Further research into the pathogenesis of multicentric intraocular melanomas is warranted.
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