Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new model for pancreatitis

K Satake1, A Hiura

  • 1First Department of Surgery, Osaka City University Medical School, Osaka, Japan.

Pancreas
|April 21, 1998
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel rat model for pancreatitis, allowing simultaneous study of damaged and healthy pancreatic tissue. A protease inhibitor showed a hypertrophic effect in this model, useful for drug and cancer research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early tumour response assessment may avoid serious immune-related adverse events in nivolumab and ipilimumab combination therapy for stage IV melanoma.

The British journal of dermatology·2021
Same author

Combined carboplatin and paclitaxel therapy improves overall survival in patients with nivolumab-resistant acral and mucosal melanoma.

The British journal of dermatology·2021
Same author

The effect of the lymphovascular plugging metastasis pattern in extramammary Paget disease on identifying metastatic lesions using imaging tests: an autopsy case series.

The British journal of dermatology·2019
Same author

Single-agent taxane is useful in palliative chemotherapy for advanced extramammary Paget disease: a case series.

The British journal of dermatology·2019
Same author

Chemoradiotherapy could improve overall survival of patients with stage IV cutaneous squamous cell carcinoma: analysis of 34 cases.

The British journal of dermatology·2019
Same author

Efficacy of nivolumab monotherapy against acral lentiginous melanoma and mucosal melanoma in Asian patients.

The British journal of dermatology·2018
Same journal

ITGB4 Activates the Pentose Phosphate Pathway to Reduce the Sensitivity of Pancreatic Adenocarcinoma to Gemcitabine.

Pancreas·2026
Same journal

AI-driven Test-Free Prediction of ICU Admission, Insulin Dependence, and Exocrine Dysfunction after Acute Pancreatitis.

Pancreas·2026
Same journal

Redefining Prognosis in Acute Pancreatitis: The Emerging Role of Antioxidant Biomarkers.

Pancreas·2026
Same journal

Commentary on "High Rate of Exocrine Pancreatic Dysfunction in Pediatric Patients with Diabetes Mellitus".

Pancreas·2026
Same journal

Pancreatic Ductal Adenocarcinoma (PDAC) Arising from Mixed Duct Intraductal Papillary Mucinous Neoplasm (IPMN) can Mimic Multifocal Pseudocyst.

Pancreas·2026
Same journal

Adult Chronic Pancreatitis Working Group: Goals, Accomplishments and the Path Ahead. A Report from the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.

Pancreas·2026
See all related articles

Area of Science:

  • Gastroenterology
  • Surgical Pathology
  • Pharmacology

Background:

  • Pancreatitis research often uses pancreatic duct ligation models, challenging in small animals and difficult for drug efficacy evaluation due to inter-species variability.
  • Existing models lack a direct comparison of treatment effects on both damaged and healthy pancreatic tissue within the same subject.

Purpose of the Study:

  • To develop a refined small-animal model for pancreatitis that allows for simultaneous biochemical and histological assessment of both injured and normal pancreatic tissue.
  • To evaluate the preliminary efficacy of a novel protease inhibitor, ONO-3404, in this new pancreatitis model.

Main Methods:

  • A novel surgical technique involving ligation of the main pancreatic duct in the splenic lobe using absorbable sutures in rats, while leaving the gastroduodenal lobe intact.

Related Experiment Videos

  • Biochemical and histological analyses were performed to assess pancreatic tissue damage and regeneration.
  • The effect of the protease inhibitor ONO-3404 was evaluated on both the ligated (damaged) and intact (normal) pancreatic lobes within the same animal.

    • Main Results:

    • The developed model successfully created distinct regions of damaged and normal pancreatic tissue within the same rat.
    • The protease inhibitor ONO-3404 demonstrated a hypertrophic effect on both the damaged and normal pancreatic tissues.
    • The model proved effective for evaluating drug effects and studying pancreatic insufficiency and carcinogenesis.

    Conclusions:

    • This novel, localized pancreatic duct ligation model in rats provides a robust platform for studying pancreatitis.
    • It facilitates the direct comparison of therapeutic effects on both diseased and healthy pancreatic tissue in a single subject.
    • The model holds promise for advancing research in pharmaceutical treatments for pancreatic conditions and pancreatic carcinogenesis.