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Related Experiment Videos

Chronic pancreatitis: functional testing

K Ochi1, T Mizushima, H Harada

  • 1Department of Laboratory Medicine, Okayama University Medical School, Okayama-shi, Japan.

Pancreas
|April 21, 1998
PubMed
Summary
This summary is machine-generated.

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The review covers the evolution of pancreatic function tests in Japan, from older methods to the gold standard secretin (S) test and newer, less invasive alternatives for chronic pancreatitis (CP) diagnosis and management.

Area of Science:

  • Gastroenterology
  • Pancreatic Physiology
  • Diagnostic Testing

Background:

  • Diagnosis of chronic pancreatitis (CP) historically relied on symptoms and less specific tests.
  • The secretin (S) test became the gold standard for exocrine pancreatic function assessment in Japan.
  • The S test is invasive and cumbersome, prompting the development of simpler alternatives.

Purpose of the Study:

  • To review the historical evolution of pancreatic functional testing in Japan for CP.
  • To contrast diagnostic methods in the pre-S test and post-S test eras.
  • To evaluate the utility of newer, non-invasive tests for CP monitoring.

Main Methods:

  • Review of diagnostic criteria and functional tests for CP in Japan.
  • Comparison of the secretin (S) test with pre-S test methods (symptoms, serum diastase, vagostigmine/ether stimulation).

Related Experiment Videos

  • Evaluation of newer tests: N-benzoyl-L-tyrosal-p-aminobenzoic acid (BT-PABA) and fecal chymotrypsin testing.

    • Main Results:

    • The secretin (S) test and CCK-pancreozymin (PZ) test (PS test) were introduced in Japan around 1963 and standardized over time.
    • Despite standardization, the S test remains invasive.
    • N-benzoyl-L-tyrosal-p-aminobenzoic acid (BT-PABA) and fecal chymotrypsin tests, introduced in the 1970s, are less sensitive/specific than the S test but useful for monitoring.

    Conclusions:

    • The secretin (S) test has been the gold standard for exocrine pancreatic function in Japan, but its invasiveness led to the adoption of simpler tests.
    • Newer tests like BT-PABA and fecal chymotrypsin are valuable for monitoring CP and treatment efficacy.
    • The glucose tolerance test aids in detecting endocrine pancreatic insufficiency.