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Combination of LC-MS and LC-NMR as a Tool for the Structure Determination of Natural Products
1Department of Chemistry, University of Hohenheim, D-70593 Stuttgart, Germany, and Varian GmbH, D-64289 Darmstadt, Germany.
Journal of Natural Products
|April 21, 1998
Abstract:
Application of both LC-MS and LC-NMR to a partially purified extract of Vernonia fastigiataled to the direct identification of antibacterial sesquiterpene lactones 1-9 without isolation of individual compounds. The rapid structural analysis of both major and minor components of this class of compounds demonstrated the power of structure-guided screening as a complementary method to assay-guided screening.