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Updated: Aug 12, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
New Briarane Stecholide Diterpenes from the Indonesian Gorgonian Briareum sp
1Departamento de Química Fundamental e Industrial, Facultade de Ciencias, Universidade da Coruña, 15071 A Coruña, Spain.
Abstract:
The Indonesian gorgonian Briareum sp. has afforded two new briarane stecholide diterpenes: 2,9-diacetyl-2-debutyrylstecholide H (1) and 13-dehydroxystecholide J (2), the semisynthetic 2beta-acetoxy-2-(debutyryloxy)stecholide E acetate (3), which was isolated as a natural product for the first time, along with the known compounds stecholides I-M (4-8), stecholide A acetate (9), and stecholide C acetate (10). The structures of the new compounds were deduced by extensive NMR studies (1H, 13C, 1H-1H COSY, NOESY, HMQC, and HMBC) and FABMS data (HR and LR). Cytotoxic activity was found for the first time in stecholide L (7).
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