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Determination of the optimum mixing time for a mixture of lactose and colloidal silicon dioxide
U Sindel1, A Schweiger, I Zimmermann
1Department of Pharmaceutical Technology, Institute of Pharmacy, University of Wuerzburg, F.R.G.
Journal of Pharmaceutical Sciences
|April 21, 1998
Abstract:
The homogeneity of a mixture of colloidal silicon dioxide (CSD) and lactose is examined by quantifying the dependence of the CSD content on the mixing time. CSD concentration is determined photometrically as a blue silica-molybdic complex. Its deviation from the expected content is taken to characterize the mixture quality and the optimum mixing time. The conformity of this result with the flow properties of the same mixture is studied by measuring the dependence of the angle of repose on the mixing time.