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[Recent development of nucleic acid drug]
A Murakami1, T Yamaoka, R Iwase
1Kyoto Institute of Technology, Department of Polymer Science and Engineering.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 29, 1998
Summary
Oligonucleotides regulate gene expression via antisense strategies, showing potential as nucleic acid drugs. These molecules, including ribozymes and aptamers, offer diverse gene regulation abilities for future clinical applications.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Context:
- Oligonucleotides and their analogs have been researched for gene expression regulation since the 1970s.
- The antisense strategy, a key application, is now moving towards clinical therapeutic use.
- Recent developments reveal diverse gene regulatory capabilities of nucleic acids.
Purpose:
- To review the diverse abilities of nucleic acids in regulating gene expression.
- To highlight the progression of antisense strategies towards clinical applications.
- To explore the potential of various nucleic acid-based molecules as future therapeutic agents.
Summary:
- Nucleic acids, including oligonucleotides, can regulate gene expression through various mechanisms.
- These mechanisms encompass antisense strategies, ribozymes, antigenes, decoy DNA/RNA, and aptamers.
- The development of these nucleic acid-based approaches paves the way for novel therapeutic applications.
Impact:
- Establishes the foundation for nucleic acid-based therapeutics.
- Identifies multiple classes of molecules with therapeutic potential for gene regulation.
- Suggests a promising future for nucleic acid drugs in clinical practice.