Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Controlled release using temperature-responsive poly(N-isopropylacrylamide) gel]

¹Institute of Applied Biochemistry, University of Tsukuba.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|April 29, 1998

Summary

Poly (N-isopropylacrylamide) (PNIPAAm) gels exhibit temperature-dependent swelling, enabling controlled drug release. This thermosensitive characteristic allows for unique pulsatile or on-off drug delivery systems.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Safety and feasibility of D3 lymph node dissection in oldest-old patients undergoing colorectal cancer surgery: a multi-institutional, retrospective analysis.

Techniques in coloproctology·2025

Same author

Pretreatment nutritional indices are associated with survival and T-cell exhaustion in recurrent or metastatic oral squamous cell carcinoma patients treated with immune checkpoint inhibitors: a retrospective cohort study.

International journal of oral and maxillofacial surgery·2025

Same author

Gastrointestinal: Intraductal papillary-mucinous carcinoma of the pancreas originating in the Santorini duct.

Journal of gastroenterology and hepatology·2022

Same author

Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression.

Journal of dental research·2019

Same author

Erratum to: Measurement of the <i>W</i> boson polarisation in <math></math> events from <i>pp</i> collisions at <math> </math> in the lepton + jets channel with ATLAS.

The European physical journal. C, Particles and fields·2019

Same author

Precision measurement and interpretation of inclusive

The European physical journal. C, Particles and fields·2018

Area of Science:

Polymer Science
Materials Science
Biomedical Engineering

Context:

Poly (N-isopropylacrylamide) (PNIPAAm) hydrogels display a sharp volume phase transition in response to small temperature changes.
This thermosensitive behavior is crucial for developing smart drug delivery systems.
Previous research established drug release profiles based on the temperature-dependent swelling of PNIPAAm gels.

Purpose:

To investigate the controlled drug release capabilities of Poly (N-isopropylacrylamide) gels.
To leverage the thermosensitive swelling-deswelling properties of PNIPAAm for unique drug release profiles.
To explore molecular design and synthesis of PNIPAAm-based gels for enhanced drug delivery.

Summary:

PNIPAAm gels exhibit discontinuous swelling-deswelling transitions with minor temperature fluctuations.

Related Experiment Videos

The temperature-dependent swelling ratio of PNIPAAm gels was utilized to achieve controlled release of indomethacin.

Novel drug release profiles, including pulsatile and on-off release, were successfully designed.

Ongoing research focuses on molecular design and synthesis of advanced PNIPAAm-based thermosensitive gels.

Impact:

Demonstrates the potential of thermosensitive PNIPAAm gels for sophisticated drug delivery applications.
Provides a foundation for designing tunable drug release systems based on external temperature stimuli.
Highlights the importance of polymer architecture in achieving specific release kinetics.
Paves the way for developing next-generation smart materials for pharmaceutical applications.