Related Experiment Video
Updated: Aug 13, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Dose from syringe procedures during technetium-99m radiopharmaceutical preparation
S G Prussin1, G Theofanous, D Casey
1Department of Nuclear Engineering, University of California Berkeley 94720, USA.
Handling Technetium-99m (99mTc) in syringes results in a 2-5 times higher dose burden compared to generator eluate. Lead X-rays from syringe shields significantly contribute to pharmacist hand dose.
Area of Science:
- Nuclear medicine
- Radiopharmacy
- Radiation safety
Background:
- Central pharmacies handle significant amounts of radioactive materials.
- Accurate dose assessment is crucial for radiation protection of healthcare professionals.
Purpose of the Study:
- To quantify dose burdens from Technetium-99m (99mTc) in syringes and shielded vials within a pharmacy setting.
- To compare dose rates from different handling methods.
Main Methods:
- Measured absorbed dose rates using CaF2 dosimeters.
- Simulated dose rates using Monte Carlo modeling.
- Assessed dose at the syringe plunger end for syringes and vials.
Main Results:
- Dose rates for 99mTc in shielded syringes were 1.35-1.62 mGy/hr/GBq.
- Dose rates for 99mTc in shielded vials were approximately 0.40 mGy/hr/GBq.
- Monte Carlo simulations accurately reproduced experimental results.
Conclusions:
- Syringe handling of 99mTc increases dose burden significantly compared to calibrating eluate.
- Lead K x-rays from shielding may contribute substantially to pharmacist hand dose.
More Related Videos
09:03Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
Published on: October 22, 2019
09:55Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
Published on: October 4, 2024
Related Concept Videos
Radiological Investigation I: X-ray and CT
Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
Imaging Studies III: Computed Tomography