Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perchlorate and the thyroid gland

J Wolff1

  • 1Laboratory of Biochemical Pharmacology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Pharmacological Reviews
|April 29, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to the comment on "Robotic-controlled laser osteotome versus manually controlled osteotomy for interdental osteotomies: a cadaveric study".

International journal of oral and maxillofacial surgery·2026
Same author

Robotic-controlled laser osteotome versus manually controlled osteotomy for interdental osteotomies: a cadaveric study.

International journal of oral and maxillofacial surgery·2025
Same author

Automated and app-based activation of first responders for prehospital cardiac arrest: an analysis of 16.500 activations of the KATRETTER system in Berlin.

Scandinavian journal of trauma, resuscitation and emergency medicine·2023
Same author

Forecasting admissions in psychiatric hospitals before and during Covid-19: a retrospective study with routine data.

Scientific reports·2022
Same author

Outcomes of gallstone complications during the COVID pandemic.

The British journal of surgery·2021
Same author

[Prioritization of intensive medical treatment places - Concept proposal].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2021
Same journal

Aryl hydrocarbon receptor pharmacology-mechanisms, ligands, and therapeutic potential.

Pharmacological reviews·2026
Same journal

Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches.

Pharmacological reviews·2026
Same journal

Translational medications development for methamphetamine use disorder: A systematic review of preclinical, human laboratory, and clinical research.

Pharmacological reviews·2026
Same journal

Reharnessing the therapeutic potential of gallium-based compounds in oncology: From the laboratory to the clinic.

Pharmacological reviews·2026
Same journal

Pharmacogenomics of antibacterial and antiviral therapies: Clinical actionability, evidence gaps, and future directions.

Pharmacological reviews·2026
Same journal

International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.

Pharmacological reviews·2026
See all related articles

Perchlorate blocks iodide uptake by the thyroid, reducing thyroid hormone synthesis and protecting against excess iodide effects. It is useful for treating thyrotoxicosis, especially when combined with thionamides.

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Perchlorate inhibits thyroid hormone synthesis by blocking iodide uptake via the Na+/I- symporter.
  • It is concentrated in thyroid tissue but not significantly metabolized.

Purpose of the Study:

  • To elucidate the mechanisms and therapeutic applications of perchlorate in thyroid dysfunction.
  • To evaluate its efficacy in managing thyrotoxicosis and iodide-induced hypothyroidism.

Main Methods:

  • Competitive inhibition of iodide transport.
  • Therapeutic use in thyrotoxicosis and amiodarone-induced thyroid dysfunction.
  • Assessment of radioiodide discharge from the thyroid.

Main Results:

  • Perchlorate effectively reduces thyroid hormone synthesis and protects against iodide overload.

Related Experiment Videos

  • Combined therapy with thionamides is beneficial for severe thyrotoxicosis.
  • Lower doses and shorter durations improve safety profiles.

    • Conclusions:

    • Perchlorate is a valuable therapeutic agent for managing thyroid disorders, particularly thyrotoxicosis and iodide excess.
    • Its dual action on hormone synthesis and inhibitor formation offers comprehensive thyroid regulation.
    • Safe and effective use is enhanced with optimized dosing and combination therapy.