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Gonadotropin pulsations across development

F J Hayes1, W F Crowley

  • 1Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.

Hormone Research
|April 29, 1998
PubMed
Summary
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The reproductive axis relies on gonadotropin-releasing hormone (GnRH) pulses. Free alpha-subunit (FAS) is a superior marker for tracking GnRH dynamics compared to luteinizing hormone (LH).

Area of Science:

  • Endocrinology
  • Neuroendocrinology
  • Reproductive Biology

Background:

  • The human reproductive axis initiation and maintenance depend on hypothalamic gonadotropin-releasing hormone (GnRH) pulsatile secretion.
  • Monitoring GnRH secretion typically involves measuring pituitary glycoprotein products: luteinizing hormone (LH), follicle-stimulating hormone (FSH), and free alpha-subunit (FAS).

Purpose of the Study:

  • To evaluate the efficacy of FAS as a surrogate marker for GnRH secretory dynamics.
  • To describe the developmental changes in GnRH secretion patterns.

Main Methods:

  • Analysis of peripheral blood samples to measure LH, FSH, and FAS levels.
  • Comparison of FAS and LH as indicators of GnRH pulsatility under various physiological conditions.

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Main Results:

  • Free alpha-subunit (FAS) demonstrates superiority over LH as a marker for GnRH secretory dynamics, particularly during rapid GnRH release or diminished LH pituitary response.
  • GnRH secretion patterns exhibit significant developmental changes, including neonatal surge, mid-childhood quiescence, pubertal reactivation, and adult pulsatility (approx. every 2 hours in males, cyclically in females).

Conclusions:

  • FAS is a more reliable surrogate marker for assessing GnRH pulsatile secretion than LH.
  • The pulsatile nature of GnRH secretion is crucial for reproductive axis function, allowing for modulated feedback mechanisms and maintenance during stress.