Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phaeomelanic pigments from a human melanoma

G Prota, H Rorsman, A M Rosengren

    Experientia
    |August 15, 1976
    PubMed
    Summary

    Melanoma pigments were analyzed for solubility and sulfur content. One pigment was identified as phaeomelanin, while the other, though eumelanic, showed a higher sulfur content than typical.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Kinetics of the humoral and cellular immune response up to 1 year from mpox virus infection.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2025
    Same author

    [The levonogestrel-releasing intrauterine device and endometrial cancer: a potential opportunity for young women].

    Minerva ginecologica·2014
    Same author

    Biochemical sites of gene action for melanogenesis in mammals.

    Annales de genetique et de selection animale·2012
    Same author

    [Not Available].

    Annales de genetique et de selection animale·2012
    Same author

    QSAR models for predicting enzymatic hydrolysis of new chemical entities in 'soft-drug' design.

    Bioorganic & medicinal chemistry·2009
    Same author

    Metabolically labile cannabinoid esters: a 'soft drug' approach for the development of cannabinoid-based therapeutic drugs.

    Bioorganic & medicinal chemistry letters·2007

    Area of Science:

    • Biochemistry
    • Dermatology
    • Melanoma Research

    Background:

    • Melanins are complex biopolymers responsible for pigmentation in humans and animals.
    • Understanding the chemical composition of melanins in melanoma is crucial for diagnosis and treatment.
    • This study investigates the properties of melanoma pigments from two distinct patients.

    Observation:

    • Pigment from a red-blonde haired patient was alkali-soluble with high sulfur content (9-10%), characteristic of phaeomelanin.
    • Pigment from a red-brown haired patient was insoluble in alkali but had a sulfur content of 6%.

    Findings:

    • The alkali-soluble pigment was definitively classified as phaeomelanin.
    • The alkali-insoluble pigment exhibited eumelanic solubility but an unusually high sulfur content for eumelanin.
    • This suggests potential variations or subtypes within eumelanin composition.

    Implications:

    • These findings contribute to a more nuanced understanding of melanoma pigment diversity.
    • Characterizing melanoma pigments may offer new avenues for diagnostic markers or therapeutic targets.
    • Further research is needed to explore the implications of high sulfur content in eumelanin.

    Related Experiment Videos