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Circular dichroism studies of some aralkylamines
Il Farmaco; Edizione Scientifica
|August 1, 1976
Summary
This study reports circular dichroism curves for various aralkylamines and related compounds. Simple correlations were deduced between the absolute configuration of these molecules and the signs of their Cotton effects.
Area of Science:
- Organic Chemistry
- Spectroscopy
- Stereochemistry
Background:
- Circular dichroism (CD) spectroscopy is a powerful tool for probing molecular chirality.
- Aralkylamines represent a class of compounds with diverse stereochemical properties.
- Understanding the relationship between molecular structure and CD spectra is crucial for stereochemical assignment.
Purpose of the Study:
- To investigate the circular dichroism (CD) properties of various aralkylamines.
- To analyze the Cotton effects associated with aromatic chromophore absorption bands (1Lb and 1La).
- To establish correlations between the absolute configuration of aralkylamines and the observed signs of Cotton effects.
Main Methods:
- Measurement of circular dichroism (CD) curves for a series of aralkylamines and related compounds.
- Analysis of CD spectra, focusing on Cotton effects related to specific aromatic absorption bands.
- Deduction of structure-spectra relationships.
Main Results:
- Reported CD curves for aralkylamines (R--CH(NH2)--R') and specific compounds like 1-aminobenzocyclobutene and amino-tetrahydronaphthalenes.
- Discussed Cotton effects arising from 1Lb and 1La aromatic chromophore absorption.
- Established simple correlations between absolute configuration and the signs of Cotton effects.
Conclusions:
- Circular dichroism spectroscopy effectively characterizes the stereochemistry of aralkylamines.
- The sign of Cotton effects provides a reliable indicator of absolute configuration in these compounds.
- This work contributes to the stereochemical analysis of chiral amines using spectroscopic methods.