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Familial hemiplegic migraine with irreversible brain damage
R Hayashi1, H Tachikawa, R Watanabe
1Department of Neurology, Yokohama City Hospital, Kanagawa.
Internal Medicine (Tokyo, Japan)
|April 29, 1998
Summary
Familial hemiplegic migraine (FHM) can cause prolonged auras leading to severe neurological deficits. This case highlights irreversible brain damage from an atypical FHM aura, confirmed by MRI.
Area of Science:
- Neurology
- Neuroimaging
- Genetics
Background:
- Familial hemiplegic migraine (FHM) is an autosomal dominant disorder.
- Characterized by recurrent hemiparesis and migraine episodes.
- Severe attacks may involve confusion or coma.
Observation:
- A case of FHM with an atypically prolonged aura is presented.
- The prolonged aura led to irreversible brain deficit.
- Initial MRI suggested cortical hyperperfusion.
Findings:
- Magnetic resonance imaging (MRI) revealed cortical hyperperfusion during the event.
- A follow-up MRI demonstrated significant left brain atrophy.
- This indicates a severe, potentially permanent neurological consequence.
Implications:
- This case underscores the potential for severe, lasting brain injury in FHM.
- Highlights the importance of advanced neuroimaging in FHM diagnosis.
- Suggests a need for further research into FHM pathophysiology and treatment.