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Related Experiment Videos

Continuing organizer function during chick tail development

V Knezevic1, R De Santo, S Mackem

  • 1Laboratory of Pathology, NCI, NIH, Bethesda, MD 20892, USA.

Development (Cambridge, England)
|June 18, 1998
PubMed
Summary

Vertebrate tail development continues gastrulation processes, with the tail bud acting as a

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Area of Science:

  • Developmental biology
  • Embryology
  • Molecular biology

Background:

  • Vertebrate posterior body development is delayed compared to gastrulation.
  • In amniotes, the tail bud replaces the regressed node and primitive streak.
  • Previous studies suggest amniote tail development is a continuation of gastrulation.

Purpose of the Study:

  • To confirm if amniote tail development is a continuation of gastrulation.
  • To investigate the molecular markers and cell movements in the chick tail bud.
  • To determine if the chick tail bud possesses organizer activity.

Main Methods:

  • Analysis of molecular marker distribution in the chick tail bud.
  • Observation of cell ingression movements in the early chick tail bud.
  • Grafting experiments using the chick tail bud as a 'tail organizer'.

Main Results:

  • Molecular marker distribution in the tail bud mirrors gastrulation patterns.
  • Gastrulation-like cell ingression occurs in the early chick tail bud.
  • The chick tail bud exhibits organizer activity, inducing new embryonic axes.

Conclusions:

  • Chick tail development is mechanistically continuous with gastrulation.
  • The developing chick tail serves as a model to study gastrulation's inductive interactions.
  • Residual tail organizing activity persists late into development.

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