Related Experiment Videos
Negative influence of RasG on chemoattractant-induced ERK2 phosphorylation in Dictyostelium
Biochimica Et Biophysica Acta
|April 29, 1998
Abstract:
The Dictyostelium ERK2 protein is transiently activated when cells are treated with the chemotactic agents cAMP or folic acid. Activating phosphorylation is markedly inhibited in strains overexpressing the constitutively activated RasG protein. This is in marked contrast to mammalian cells where the highly related mitogen-activated protein kinases (MAPKs) are stimulated by Ras activation.