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Nucleic Acids and Nucleotides

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Related Experiment Video

Updated: Feb 14, 2026

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

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[Acyclic nucleotide analogues based on phosphonic acids]

E V Efimtseva¹, S N Mikhaĭlov, M V Fomicheva

¹Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Bioorganicheskaia Khimiia

|April 29, 1998

Summary

Researchers synthesized novel nucleotide analogues containing ethylphosphonic acid. These compounds, featuring a rigid amide or double bond structure, were evaluated for antiviral and cytotoxic activities in cell cultures.

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Area of Science:

Medicinal Chemistry
Organic Synthesis
Virology

Background:

Nucleotide analogues are crucial in antiviral and anticancer therapies.
Ethylphosphonic acid derivatives offer unique structural properties for drug design.

Purpose of the Study:

To synthesize novel nucleotide analogues incorporating ethylphosphonic acid.
To investigate the antiviral and cytotoxic potential of these new compounds.

Main Methods:

Organic synthesis of ethylphosphonic acid-based nucleotide analogues.
Incorporation of rigid structural elements (amide or double bond).
In vitro evaluation of antiviral and cytotoxic activities in cell cultures.

Main Results:

Successful synthesis of novel nucleotide analogues with defined rigid structures.
Demonstration of varying degrees of antiviral activity against selected viruses.
Identification of compounds exhibiting significant cytotoxic effects on cancer cell lines.

Conclusions:

The synthesized ethylphosphonic acid nucleotide analogues represent a promising class of compounds.
These analogues warrant further investigation for therapeutic development.
The rigid structural elements are key to their observed biological activities.