Structural brain imaging in schizophrenia

The subtle pathomorphology of schizophrenia is gradually being unraveled through the application of increasingly sophisticated brain imaging techniques. There is now compelling evidence of subtle brain abnormalities in patients with schizophrenia. It less clear, however, whether these reflect a widespread cortical involvement, or more selective involvement among interconnected neural systems, or more focal pathology. The extent of brain changes, their etiopathologic significance, and putative clinical correlates are reviewed in this article.