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Updated: Aug 17, 2026

GC-based Detection of Aldononitrile Acetate Derivatized Glucosamine and Muramic Acid for Microbial Residue Determination in Soil
Published on: May 19, 2012
Determination of sulfonamide antibiotics by gas chromatography coupled with atomic emission detection
B Chiavarino1, M E Crestoni, A Di Marzio
1Dipartimento di Studi Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università di Roma La Sapienza, Italy.
Abstract:
The paper describes the analysis of nine sulfonamides, chosen as the most widely used representatives of an important class of antibacterial drugs. Atomic emission detection has been found to allow simultaneous quantification and identification of the N1-methylated derivatives, which are resolved efficiently by conventional capillary gas chromatography. Results are given concerning the linearity of the response and the characterization of the individual compounds by the elemental ratio of their carbon, nitrogen and sulfur content. The method looks promising for the quantitative analysis and confirmation of sulfonamide residues in complex mixtures.
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