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Related Experiment Videos

Phenytoin sodium microcapsules: bench scale formulation, process characterization and release kinetics

E Yazici1, L Oner, H S Kaş

  • 1Pharmacy Faculty, Hacettepe University, Ankara, Turkey.

Pharmaceutical Development and Technology
|July 1, 1996
PubMed
Summary

Sustained-release phenytoin sodium microcapsules were developed using ethylcellulose and Eudragit copolymers. Optimized formulations achieved desired drug release profiles, demonstrating potential for improved epilepsy treatment.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Phenytoin sodium is a key antiepileptic drug.
  • Developing sustained-release formulations improves therapeutic efficacy and patient compliance.
  • Microencapsulation offers a viable approach for controlled drug release.

Purpose of the Study:

  • To formulate and prepare sustained-action microcapsules of phenytoin sodium.
  • To evaluate the in vitro release characteristics of the microcapsules.
  • To optimize the formulation for desired drug release profiles.

Main Methods:

  • Microencapsulation using organic phase separation and granule coating methods.
  • Utilizing ethylcellulose and Eudragit S-100/L-100 as coating materials.

Related Experiment Videos

  • Phase diagram analysis, in vitro release studies (USP XXIII rotating basket), factorial design, and multiple regression analysis.

    • Main Results:

    • Phase diagrams indicated optimal conditions for ethylcellulose residue and nonsolvent amount.
    • Formulations E-5, ES-2, and ESL-2 achieved desired phenytoin sodium release profiles.
    • The optimal phenytoin sodium-to-ethylcellulose ratio was determined to be 1:2.3.

    Conclusions:

    • Sustained-action phenytoin sodium microcapsules were successfully formulated.
    • The developed microcapsules exhibit controlled in vitro drug release.
    • The study provides a basis for optimizing microencapsulation parameters for sustained drug delivery.